Cannabinoid Hyperemesis Syndrome (CHS) is a physiological medical condition triggered by long-term, heavy cannabis use.

Clinical Progression

CHS typically unfolds in three distinct phases:

• Prodromal Phase: Early morning nausea and mild abdominal discomfort. Often misidentified, leading some patients to increase cannabis use for perceived relief.
• Hyperemetic Phase: Cyclical, overwhelming vomiting (up to 5 times per hour) and intense abdominal pain. A classic clinical sign is temporary relief obtained via hot baths or showers.
• Recovery Phase: Complete cessation of cannabis leads to symptom resolution, starting within days to two weeks, though full recovery can take months. Resuming use triggers relapse.

Etiology & Prevalence

As documented by page-3191881, the condition is driven by chronic overstimulation of cannabinoid receptors (especially in the gastrointestinal tract). High THC potency has increased prevalence. It primarily affects daily users of over one year, particularly those aged 16–34, with elevated risk linked to early-age cannabis initiation (<16) and concurrent tobacco use.